Meredith Grey (Ellen Pompeo)

Derek Shepherd (Patrick Dempsey)

George O'Malley (T.R. Knight)

Cristina Yang (Sandra Oh)

Isobel "Izzie" Stevens (Katherine Heigl)

Alex Karev (Justin Chambers)

Preston Burke (Isaiah Washington)

Miranda Bailey (Chandra Wilson)

Richard Webber (James Pickens Jr.)

Addison Montgomery-Shepherd (Kate Walsh)

Callie Torres (Sara Ramirez)

Mark Sloan (Eric Dane)

Lexie Grey (Chyler Leigh)